Many of you perhaps have seen the movie “The Curious Case of
Benjamin Burton” a fantasy drama movie If you haven’t seen the
movie I highly recommend. The movie presents the life of Benjamin Burton (Brad
Pitt) who reverse age as he grew older.
This is a fiction movie. Reversing aging and aging backwards
is something unreal. What the new scientific breakthrough can say about aging?
One interested book that I’ve read in the last time is
Lifespan written by David Sinclair. I have been watching David Sinclair in the
last years. For those who don’t know who David Sinclair is is professor of
Department of Genetics at Harvard Medical School.
I always have been obsessed with the idea of aging and I’m
still. We’ve been taught that that aging is something that come naturally, but
is still this true? Can we stop aging? Delay it? And why not to reverse it?
Lifespan is a book that gives some insights and scientific notes
about aging. Aging is associated with many diseases like cancers,
cardiovascular, neurogenerative (Alzheimer and Parkinson) and frailty to name a
few of them.
Aging Can be attributed to the following factors and present the following hallmarks:
- Genomic instability caused by DNA damage
- Accumulation of senescent cells (zombie cells)
- Alteration of the chromosomes that affect telomeres
- Mitochondrial dysfunction
Over the years aging had many definitions started with something that come naturally as time pass, shorten of the telomeres all of these are wrong.
We can define aging as the process of loss of information. Epigenetic changes cause aging. To understand this, we have our DNA which is the digital information, we can make an analogy with a compact disk and the Epigenome the reader that read songs.
Epigenome is the structure that is wrapped with DNA around
protein histones which say what genes should be turn on/off. What cause aging
are scratches and distractions on the compact disk making to skip the songs. Skipping
to read the song makes the cells to read the wrong genes and the ability to
fight diseases.
Resseting the Epigenome
Sirtuins : SIRT1, SIRT6 and SIRT6 (Silent Information Regulation) are critical for the control of epigenome and DNA repair. Other form of SIRT3,4,5 help mitochondria and control energy metabolism. The good news here is that we can reset the epigenome by polishing the CD and get back to original copy.
What can be done?
The first thing that we can do is to put our body in a
survival circuit hormesis by tweaking sirtuins, mTOR and AMPK. Sirt2 control
the Epigenome. When a DNA break occurs SIRT2 is recruited repair the damage. On
average more than 2 trillion breaks occurs to our DNA.
David Sinclair recommends the following:
- Intermittent fasting restricting your caloric intake is one of the best choices that a person can do. Inhibiting mToR (Mammalian Target Rapamycin) force cells to spend less energy and recycle old proteins.
- Exercise (High Intensive Intervals) Sinclair recommends those exercise that lose your breath for few minutes to induce the body in the hypoxia state.
- Resveratrol is chemical compound found special in red grapes, cacao and berries. Resveratrol activates Sirtuins
- NMN Supplement Nicotinomide Mononucleotide is an NAD booster. Without NAD our life cannot be possible even for a few seconds. Once we age the level of NAD(Nicotinemide Adenine Dinucleotide) start to decline.
- Metformin is a drug normally recommended for people with 2 Type Diabetes. Is considered one of the safest drug in the world. Metformin helps increase the lifespan by mimicking caloric restriction activating AMPK and also activate SIRT1
- Hot/Cold showers Recent studies demonstrated that cold showers promote brown fat production can help improve health by increasing the lifespan
- Genetic Reprogramming on the early stage of development. Is one the promising technology, tests that had been done over animals (mice) are mind blowing. I consider these technology the only one that can reverse aging quick.
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